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Akkermansia muciniphila

Toxicological safety evaluation of pasteurized Akkermansia muciniphila. Druart C, Plovier H, Van Hul M, Brient A, Phipps KR, de Vos WM, Cani PD.J Appl Toxicol. 2020 Jul 28. doi: 10.1002/jat.4044.

Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice. Depommier C, Van Hul M, Everard A, Delzenne NM, De Vos WM, Cani PD. Gut Microbes. 2020 Sep 2;11(5):1231-1245.

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Depommier C, Everard A, Druart C, Plovier H, Van Hul M, Vieira-Silva S, Falony G, Raes J, Maiter D, Delzenne NM, de Barsy M, Loumaye A, Hermans MP, Thissen JP, de Vos WM, Cani PD. Nature Medicine. 2019 Jul;25(7):1096-1103. doi: 10.1038/s41591-019-0495-2. Epub 2019 Jul 1.

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, van der Ark KC, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD. Nature Medicine. 2017 Jan;23(1):107-113. doi: 10.1038/nm.4236. Epub 2016 Nov 28.

Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone loss. Lawenius L, Scheffler JM, Gustafsson KL, Henning P, Nilsson KH, Colldén H, Islander U, Plovier H,Cani PD, de Vos WM, Ohlsson C, Sjögren K.Am J Physiol Endocrinol Metab. 2020 Apr 1;318(4):E480-E491.
 
Akkermansia muciniphila reduces Porphyromonas gingivalis-induced inflammation and periodontal bone destruction. Huck O, Mulhall H, Rubin G, Kizelnik Z, Iyer R, Perpich JD, Haque N, Cani PD, de Vos WM, Amar S.J Clin Periodontol. 2020 Feb;47(2):202-212.
 
Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice. Katiraei S, de Vries MR, Costain AH, Thiem K, Hoving LR, van Diepen JA, Smits HH, Bouter KE, Rensen PCN, Quax PHA, Nieuwdorp M, Netea MG, de Vos WM, Cani PD, Belzer C, van Dijk KW, Berbée JFP, van Harmelen V.Mol Nutr Food Res. 2020 Aug;64(15):e1900732.
 
Akkermansia muciniphila abundance is lower in severe obesity, but its increased level after bariatric surgery is not associated with metabolic health improvement. Dao MC, Belda E, Prifti E, Everard A, Kayser BD, Bouillot JL, Chevallier JM, Pons N, Le Chatelier E, Ehrlich SD, Doré J, Aron-Wisnewsky J, Zucker JD, Cani PD, Clément K.Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E446-E459.
 
Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice. Hänninen A, Toivonen R, Pöysti S, Belzer C, Plovier H, Ouwerkerk JP, Emani R, Cani PD, De Vos WM.Gut. 2018 Aug;67(8):1445-1453.
 
Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila. Cani PD, de Vos WM.Front Microbiol. 2017 Sep 22;8:1765.
 
 
Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Dao MC, Everard A, Aron-Wisnewsky J, Sokolovska N, Prifti E, Verger EO, Kayser BD, Levenez F, Chilloux J, Hoyles L; MICRO-Obes Consortium, Dumas ME, Rizkalla SW, Doré J, Cani PD, Clément K.Gut. 2016 Mar;65(3):426-36.
 
Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Schneeberger M, Everard A, Gómez-Valadés AG, Matamoros S, Ramírez S, Delzenne NM, Gomis R, Claret M, Cani PD.Sci Rep. 2015 Nov 13;5:16643.
 
 
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD.Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71.
 
 
Akkermansia muciniphila Credit: Prof. W.M. de Vos